Cesium carbonate → 3-(2-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-6-((2,2,2-trifluoroethoxy)-methyl)pyrimidin-4-ylamino)propanenitrile

Participants

Reaction Conditions

Reaction Steps

3-(2-Chloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-ylamino)propanenitrile (29 mg, 0.10 mmol), 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (40 mg, 0.20 mmol), cesium carbonate (64 mg, 0.20 mmol), palladium(II) acetate (3 mg, 0.01 mmol), 2-(dicyclohexylphosphino)-biphenyl (5 mg, 0.01 mmol) and dioxane (1.5 mL) were mixed in a vial and kept under an atmosphere of nitrogen. The mixture was heated in a microwave reactor at 120° C. for 90 min. The mixture was filtered through at pad of diatomeous earth. The filter plug was rinsed with MeOH. The solvents were evaporated and the residue was purified by preparative HPLC to give the title compound as a solid, 22 mg (48%).

Provenance & Evidence