反应详情

To a solution of IBX (0.93 g, 3.3 mmol) in dimethylsulfoxide (3.5 mL) was added N-(4-hydroxymethyl-2-iodo-phenyl)-acetamide (0.87 g, 3.0 mmol) and the reaction mixture was stirred at room temperature for 1 hour. Water (50 mL) was added and the solid was separated by filtration, and washed with ethyl acetate (20 mL). The filtrate was collected and extracted with ethyl acetate (200 mL). The organic phase was washed with brine (100 mL) and dried over anhydrous Na2SO4. Removal of solvent gave N-(4-formyl-2-iodo-phenyl)-acetamide as a light brown solid. Yield: 0.82 g (95%).

1. customthe solid was separated by filtration
2. washwashed with ethyl acetate (20 mL)
3. customThe filtrate was collected
4. extractionextracted with ethyl acetate (200 mL)
5. washThe organic phase was washed with brine (100 mL)
6. dry with materialdried over anhydrous Na2SO4
7. customRemoval of solvent