Ammonium Chloride → HCID 86344983, compound

Participants

Reaction Steps

1-(2-(3-Methoxy-4-(2-methyloxazol-5-yl)phenylamino)-6-((2,2,2-trifluoroethoxy)methyl)-pyrimidin-4-yl)ethanone (60 mg, 0.14 mmol) was dissolved in THF (5 mL) and was added slowly to a solution of isopropyl magnesium chloride (2 M in THF, 0.206 mL, 0.41 mmol) in THF (5 mL). The mixture was stirred for 5 min. The mixture was cooled on an ice bath, ammonium chloride (sat, aq, 5 mL) was added. The mixture was stirred for 5 min. The mixture was extracted with EtOAc (×2). The solvents were evaporated and the residue was purified by column chromatography on silica eluting with a gradient of MeOH in DCM to give the title compound as a solid, 40 mg (61%).

Provenance & Evidence