反应详情

4-Hydroxymethyl-2,6-dimethylpyridine (1.00 g, 7.28 mmol) was dissolved in ethanol (20 mL), and activated MnO2 (2.24 g, 21.8 mmol) was added; the reaction mixture was refluxed for 17 hours. The mixture was cooled and concentrated, purified by column chromatography (silica gel 230-400 mesh; 20% ethyl acetate in hexanes as eluent) to give 2,6-dimethyl-4-pyridinecarboxaldehyde as a yellow oil. Yield: 0.14 g (14%).

1. temperaturethe reaction mixture was refluxed for 17 hours
2. temperatureThe mixture was cooled
3. concentrationconcentrated
4. custompurified by column chromatography (silica gel 230-400 mesh; 20% ethyl acetate in hexanes as eluent)