HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 1-(Pyrrolidin-1-ylmethyl)benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 2-(4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one | HCID 135939121 | — |
| Reactant | HCID 178418385 | HCID 178418385 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(Pyrrolidin-1-ylmethyl)benzimidazole | HCID 209096 | — |
Reaction Steps
To a suspension of 1H-benzotriazole (10.0 g, 83.9 mmol) in water (84 mL) was added pyrrolidine 2 (6.3 mL, 226.6 mmol). After 10 minutes of vigorous stirring at room temperature, formaldehyde 37% aqueous solution was added. The reaction mixture was stirred for 1 hour, then the precipitate was filtered off, and washed with water to afford 1-pyrrolidin-1-ylmethyl-1H-benzoimidazole as an off-white solid. Yield: 14.58 g (85.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238640B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-7fa88af7c63d408f97cb9b78982fcb9e |
| Source note | uspto-grants-2016_01 |