2-Nitro-5-(2-pyrrolidin-1-yl-ethyl)-benzoic acid methyl ester → 2-Amino-5-(2-pyrrolidin-1-yl-ethyl)-benzoic acid methyl ester

Participants

Reaction Steps

To a solution of 2-nitro-5-(2-pyrrolidin-1-yl-ethyl)-benzoic acid methyl ester in THF (16 mL) was added 10% palladium on charcoal (0.23 g). The resulting reaction mixture was hydrogenated under 40 psi for 2 hours, then the catalyst was filtered off and the filtrate concentrated under high vacuum to give 2-amino-5-(2-pyrrolidin-1-yl-ethyl)-benzoic acid methyl ester as a yellow oil. Yield: 1.04 g (89.6%). The crude material was used in the next step without further purification.

Provenance & Evidence