化工社化工社 化学情報印刷レポート · 研究参考用
Acetaldehyde → CID 86706182
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetaldehyde | HCID 177 | — |
| 反応物 | Obeticholic Acid | HCID 447715 | — |
| 生成物 | CID 86706182 | HCID 86706182 | — |
反応手順
The present invention relates to a process for preparing obeticholic acid Form 1, wherein reacting 3α,7-ditrimethylsilyloxy-5β-chol-6-en-24-oic acid methyl ester with CH3CHO to form E- or E/Z-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid methyl ester is carried out in a polar aprotic solvent at a temperature at about −50° C. to about −70° C. in the presence of BF3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09238673B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-ddf396e91d634ac89675b49aa9f07b20 |
| 出典メモ | uspto-grants-2016_01 |