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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 591886Generated: October 31, 2026

Sodium Hydroxide → (R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

https://huagongshe.com/reaction/591886

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactant(R)-Methyl 4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoateHCID 86706184—
Product(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acidHCID 86706183—

Reaction Steps

reacting E-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid methyl ester (4) with NaOH to form E-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid (5),

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09238673B2
Source datasetuspto-grants-2016_01
ORD IDord-5a6cef8b388c40cd84a2d92057989702
Source noteuspto-grants-2016_01