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HRID591921

反应详情

EQUATION

反应方程式

HRID 591921 的结构方程式

REACTANTS

反应物

2
结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2
HCID117701912

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F
HCID178513995

未命名化合物

PRODUCTS

生成物

1
结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4cccc(N5CCOCC5)c4)nc23)[C@H]2C=C[C@@H]1C2
HCID178513993

未命名化合物

收率 69%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 3-morpholin-j4-yl-benzaldehyde were reacted to produce the title compound (69%). 1H NMR (d-chloroform): 15.96 (br s, 1H) 8.37 (d, J=9 Hz, 1H), 7.83 (s, 1H), 7.71 (s, 1H), 7.59 (d, J=8 Hz, 1H), 7.40 (t, J=8 Hz, 1H), 7.06 (dd, J=2.8 Hz, 1H), 6.48 (m, 1H), 6.42 (m, 1H), 6.07 (br s, 1H), 5.86 (br s, 1H), 5.37 (t, J=8 Hz, 1H), 3.94 (m, 4H), 3.33 (m, 4H), 3.17 (s, 1H), 3.03 (s, 1H), 2.71 (d, J=8 Hz, 1H), 2.31 (d, J=9 Hz, 1H), 1.67 (d, J=9 Hz, 1H). MS: 466.07 (M+H). HPLC retention time: 2.41 minutes (G Method).