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HRID591926

反应详情

EQUATION

反应方程式

HRID 591926 的结构方程式

REACTANTS

反应物

3
结构：CN(C)c1cccc(C=O)c1
HCID34288

3-(dimethylamino)benzaldehyde

C9H11NO

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2
HCID117701912

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F
HCID178513995

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)c1cccc(-c2nc3c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c(Cl)cnc3[nH]2)c1
HCID178482748

未命名化合物

收率 86%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 3-Dimethylamino-benzaldehyde were reacted to produce the title compound (86%). 1H NMR (d-chloroform): 16.5 (br s, 1H), 8.37 (d, J=8 Hz, 1H), 7.83 (s, 1H), 7.72 (s, 1H), 7.61 (d, J=8 Hz, 1H), 7.45 (t, J=8 Hz, 1H), 7.06 (dd, J=2.8 Hz, 1H), 6.51 (m, 1H), 6.42 (m, 1H), 5.98 (m, 1H), 5.62 (m, 1H), 5.38 (t, J=8 Hz, 1H), 3.17 (s, 1H), 3.13 (s, 6H), 3.06 (s, 1H), 2.71 (d, J=8 Hz, 1H), 2.33 (d, J=8 Hz, 1H), 1.68 (d, J=8 Hz, 1H). MS: 424.04 (M+H). HPLC retention time: 2.06 minutes (G Method).