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HRID591928

反应详情

EQUATION

反应方程式

HRID 591928 的结构方程式

REACTANTS

反应物

3
结构：O=Cc1cccc(CN2CCOCC2)c1
HCID7164603

3-(morpholin-4-ylmethyl)benzaldehyde

C12H15NO2

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2
HCID117701912

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F
HCID178513995

未命名化合物

PRODUCTS

生成物

1
结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4cccc(CN5CCOCC5)c4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F
HCID178513989

未命名化合物

收率 77%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 3-Morpholin-4-ylmethyl-benzaldehyde were reacted to produce the title compound (77%). 1H NMR (d-chloroform): 8.78 (d, J=8 Hz, 1H), 8.20 (m, 1H), 8.09 (s, 1H), 7.85 (s, 1H), 7.63 (m, 2H), 6.42-6.50 (m, 2H), 6.01 (s, 1H), 5.61 (s, 1H), 5.38 (t, J=8 Hz, 1H), 4.37 (d, J=13 Hz, 1H), 4.27 (d, J=13 Hz, 1H), 3.99 (m, 4H), 3.53 (m, 2H), 3.18 (s, 1H), 3.05 (m, 1H), 3.04 (s, 1H), 2.70 (d, J=8 Hz, 1H), 2.32 (d, J=9 Hz, 1H), 1.68 (d, J=9 Hz, 1H). MS: 480.09 (M+H). HPLC retention time: 1.81 minutes (G Method).