2-Methoxy-4-(trifluoromethoxy)benzaldehyde → HCID 178493549, compound

Participants

Reaction Steps

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-Methoxy-4-trifluoromethoxy-benzaldehyde were reacted to produce the title compound (60%). 1H NMR (d-chloroform): 13.94 (br s, 1H), 8.31 (d, J=9 Hz, 1H), 8.20 (d, J=9 Hz, 1H), 7.83 (s, 1H), 6.97 (d, J=9 Hz, 1H), 6.82 (s, 1H), 6.44 (m, 2H), 6.24 (s, 1H), 5.82 (s, 1H), 5.35 (d, J=9 Hz, 1H), 4.11 (s, 3H), 3.17 (s, 1H), 2.97 (s, 1H), 2.74 (d, J=8 Hz, 1H), 2.31 (d, J=9 Hz, 1H), 1.65 (d, J=9 Hz, 1H). MS: 495.00 (M+H). HPLC retention time: 3.12 minutes (G Method).

Provenance & Evidence