2-Methoxy-4-(4-morpholin-4-yl-piperidin-1-yl)-benzaldehyde → HCID 178492999, compound

Participants

Reaction Steps

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-Methoxy-4-(4-morpholin-4-yl-piperidin-1-yl)-benzaldehyde were reacted to produce the title compound (75%). 1H NMR (d-6 DMSO): 12.50 (br s, 1H), 9.85 (br s, 1H), 8.09 (s, 1H), 8.04 (d, J=9 Hz, 1H), 7.83 (br s, 1H), 7.29 (s, 1H), 6.77 (d, J=9 Hz, 1H), 6.66 (s, 1H), 6.38 (s, 2H), 5.15 (m, 1H), 3.95-4.30 (m, 7H), 3.69 (t, J=10 Hz, 2H), 3.48 (m, 3H), 3.13 (m, 2H), 2.82-2.96 (m, 4H), 2.63 (d, J=8 Hz, 1H), 2.11-2.26 (m, 3H), 2.08 (s, 1H), 1.69 (m, 2H), 1.41 (d, J=9 Hz, 1H). MS: 579.20 (M+H). HPLC retention time: 1.91 minutes (G Method).

Provenance & Evidence