HCID 89726145, compound → HCID 178492995, compound

Participants

Reaction Steps

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-Methoxy-4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-benzaldehyde were reacted to produce the title compound (60%). 1H NMR (d-chloroform): 10.62 (br s, 1H), 8.22 (d, J=9 Hz, 1H), 7.98 (s, 1H), 6.66 (m, 2H), 6.50 (s, 1H), 6.33 (d, J=10 Hz, 2H), 5.07-5.19 (m, 2H), 4.03 (s, 3H), 3.90 (d, J=11 Hz, 2H), 3.49 (s, 2H), 3.17 (s, 1H), 2.89 (m, 4H), 2.65 (m, 4H), 2.46 (m, 4H), 232 (m, 1H), 2.31 (s, 3H), 1.97 (d, J=11 Hz, 2H), 1.60-1.79 (m, 3H). MS: 592.22 (M+H). HPLC retention time: 1.76 minutes (G Method).

Provenance & Evidence