3-(Dimethylamino)benzaldehyde → HCID 178482747, compound

Participants

Reaction Steps

In the same fashion as for Compound III, (1R,2R,3S,4S)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 3-Dimethylamino-benzaldehyde were reacted to produce the title compound (58%). 1H NMR (d-chloroform): 16.03 (br s, 1H), 8.36 (d, J=9 Hz, 1H), 7.82 (s, 1H), 7.74 (s, 1H), 7.61 (d, J=9 Hz, 1H), 7.45 (t, J=8 Hz, 1H), 7.09 (t, J=8 Hz, 1H), 6.50 (m, 1H), 6.42 (m, 1H), 6.04 (m, 1H), 5.69 (m, 1H), 5.37 (t, J=7 Hz, 1H), 3.17 (s, 1H), 3.13 (s, 6H), 3.04 (s, 1H), 2.71 (d, J=9 Hz, 1H), 2.33 (d, J=9 Hz, 1H), 1.68 (d, J=9 Hz, 1H). MS: 423.15 (M+H). HPLC retention time: 2.05 minutes (G Method).

Provenance & Evidence