4-(4-Methylpiperazin-1-yl)benzaldehyde → HCID 178480651, compound

Participants

Reaction Steps

In the same fashion as for Compound III, (1R,2R,3S,4S)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 4-(4-Methyl-piperazin-1-yl)-benzaldehyde were reacted to produce the title compound (66%). 1H NMR (d-chloroform): 15.63 (br s, 1H) 8.36 (d, J=9 Hz, 1H), 8.02 (d, J=9 Hz, 2H), 7.78 (s, 1H), 7.03 (d, J=9 Hz, 2H), 6.48 (m, 1H), 6.42 (m, 1H), 5.95 (s, 1H), 5.59 (s, 1H), 5.54 (t, J=8 Hz, 1H), 3.38-3.92 (m, 8H), 3.17 (s, 1H), 3.04 (m, 1H), 3.02 (s, 1H), 2.91 (s, 3H), 2.68 (d, J=9 Hz, 1H), 2.32 (d, J=9 Hz, 1H), 1.67 (d, J=9 Hz, 1H). MS: 478.15 (M+H). HPLC retention time: 1.79 minutes (G Method).

Provenance & Evidence