2-Methoxy-4-(4-methyl-piperazin-1-yl)-benzaldehyde → HCID 178493010, compound

Participants

Reaction Steps

In the same fashion as for Compound III, (1R,2R,3S,4S)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-Methoxy-4-(4-methyl-piperazin-1-yl)-benzaldehyde were reacted to produce the title compound (5%). 1H NMR (d-6 DMSO): 12.19 (br s, 1H), 9.67 (br s, 1H), 8.05 (d, J=8 Hz, 1H), 7.94 (s, 1H), 7.77 (s, 1H), 7.18 (m, 1H), 6.79 (d, J=8 Hz, 1H), 6.71 (s, 1H), 6.35 (s, 2H), 5.20 (m, 1H), 4.07 (d, J=8 Hz, 2H), 3.98 (s, 3H), 3.28-2.18 (m, 11H), 1.45 (m, 2H), 1.39 (m, 1H). MS: 508.1 (M+H). HPLC retention time: 1.82 minutes (G Method).

Provenance & Evidence