(1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide → HCID 178491968, compound

Participants

Reaction Steps

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-methoxy-4-(4-methyl-piperazin-1-ylmethyl)-benzaldehyde bis trifluoroacetate were reacted to produce the title compound (18%). 1H NMR (d-chloroform): 10.74 (s, 1H), 8.34 (d, J=7 Hz, 1H), 8.03 (s, 1H), 7.12 (m, 2H), 6.37 (m, 3H), 5.55 (d, J=8 Hz, 1H), 5.20 (t, J=7 Hz, 1H), 5.14 (br s, 1H), 4.08 (s, 3H), 3.58 (s, 2H), 3.18 (s, 1H), 2.91 (s, 1H), 2.88 (d, J=7 Hz, 1H), 2.52 (m, 4H), 2.36 (m, 1H), 2.33 (s, 3H), 1.74 (m, 4H), 1.29 (m, 1H). MS: 522.2 (M+H). HPLC retention time: 1.71 minutes (G Method).

Provenance & Evidence