HCID 89725697, compound → HCID 178487551, compound

Participants

Reaction Steps

In a similar fashion as for the synthesis of III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 4[1-((S)-2-hydroxypropyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-2-methoxybenzaldehyde were reacted to produce the title compound (44%). 1H NMR (d-4 methanol): 8.26 (d, J=7 Hz, 1H), 7.94 (s, 1H), 7.24 (m, 2H), 6.42 (m, 2H), 6.31 (s, 1H), 5.33 (m, 1H), 4.29 (m, 1H), 4.11 (s, 3H), 4.07 (m, 2H), 3.65 (m, 2H), 3.39-3.27 (m, 6H), 3.17 (m, 1H), 3.07-2.85 (m, 4H), 2.77 (d, J=7 Hz, 1H), 2.34 (d, J=7 Hz, 1H), 1.57 (d, J=7 Hz, 1H), 1.56 (d, J=7 Hz, 1H), 1.30 (d, J=7 Hz, 3H). MS: 549.19 (M+H). HPLC retention time: 1.86 minutes (G Method).

Provenance & Evidence