HCID 57036484, compound → HCID 178438901, compound

Participants

Reaction Steps

In a similar fashion as for the synthesis of III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 4-allyl-2-methoxybenzaldehyde were reacted to produce the title compound as a yellow solid (12%). Mp. 123-6° C. 1H NMR (d-chloroform): 10.83 (br s, 1H), 8.32 (d, J=8 Hz, 1H), 8.02 (s, 1H), 7.00 (d, J=7 Hz, 1H), 6.91 (s, 1H), 6.46-6.31 (m, 3H), 6.00 (m, 1H), 5.55 (d, J=10 Hz, 1H), 5.28-5.12 (m, 4H), 4.05 (s, 3H), 3.48 (d, J=7 Hz, 1H), 3.18 (s, 1H), 2.91 (s, 1H), 2.87 (d. J=7 Hz, 1H), 2.35 (d, J=8 Hz, 1H), 1.75 (d, J=8 Hz, 1H). MS: 449.9 (M+H). HPLC retention time: 2.94 minutes (G Method).

Provenance & Evidence