反应详情

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50.0 mg, 0.193 mmol) and 2-methoxy-4-(4-methyl-piperazin-1-yl)-benzaldehyde (49.7 mg, 0.212 mmol) were reacted to produce 19 mg (21%) of the title compound. mp: 185-195° C., 1H NMR (300 MHz, DMSO-d6): 11.87 (s, 1H), 8.01 (s, 1H), 7.87 (s, 1H), 7.65 (s, 1H), 7.16 (s, 1H), 6.73 (m, 1H), 6.68 (s, 1H), 6.60 (s, 1H), 6.37 (s, 1H), 6.32 (s, 2H), 3.95 (s, 4H), 2.86 (s, 1H), 2.75 (s, 1H), 2.24 (s, 4H), 1.42 (s, 1H), 1.24 (s, 1H). MS: 474 (M+H), HPLC: 1.59 min (G method).