Reaction Steps
In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50.0 mg, 0.193 mmol) and 2-methoxy-4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-benzaldehyde (67.3 mg, 0.212 mmol) were reacted to produce 19 mg (20%) of the title compound. mp: 185-195° C., 1H NMR (300 MHz, DMSO-d6): 11.84 (s, 1H), 7.99 (d, J=9 Hz, 1H), 7.87 (d, J=5 Hz, 1H), 7.65 (s, 1H), 7.16 (s, 1H), 6.72 (d, J=8 Hz, 1H), 6.67 (d, J=8 Hz, 1H), 6.58 (s, 1H), 6.37 (d, J=5 Hz, 1H), 6.32 (s, 2H), 3.95 (s, 3H), 3.90 (d, J=12 Hz, 2H), 2.87-2.74 (m, 4H), 2.59 (d, J=8 Hz, 1H), 2.33 (m, 4H), 2.23 (d, J=8 Hz, 1H), 2.14 (s, 3H), 1.86 (d, J=12 Hz, 2H), 1.50 (q, J=12 Hz, 2H), 1.42 (d, J=8 Hz, 1H). MS: 557 (M+H), HPLC: 1.58 min (G method).
