2-Methoxypyridine-3-carbaldehyde → HCID 178494112, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50 mg, 0.148 mmol) and 2-Methoxy-pyridine-3-carbaldehyde (22.3 mg, 0.163 mmol) were reacted to produce 43 mg (64%) of the title compound. mp: 201° C., 1H NMR (300 MHz, DMSO-d6): 12.64 (s, 1H), 8.45 (d, J=8 Hz, 1H), 8.32 (s, 1H), 8.07 (s, 1H), 7.75 (s, 1H), 7.22 (m, 2H), 7.17 (d, J=8 Hz, 1H), 6.39 (s, 1H), 6.36 (s, 1H), 5.23 (t, J=8 Hz, 1H), 4.05 (s, 3H), 2.89 (s, 1H), 2.78 (s, 1H), 2.62 (d, J=8 Hz, 1H), 2.25 (d, J=8 Hz, 1H), 1.39 (d, J=8 Hz, 1H). MS: 455, 457 (M+H), HPLC: 2.39 min (G method).

Provenance & Evidence