2-Morpholinonicotinaldehyde → HCID 178513979, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50 mg, 0.148 mmol) and 2-Morpholin-4-yl-pyridine-3-carbaldehyde (31.2 mg, 0.163 mmol) were reacted to produce 32 mg (42%) of the title compound. mp: 150° C., 1H NMR (300 MHz, DMSO-d6): 12.95 (s, 1H), 8.33 (d, J=5 Hz, 1H), 8.04 (s, 1H), 7.98 (d, J=8 Hz, 1H), 7.73 (s, 1H), 7.19 (s, 1H), 7.09 (m, 1H), 6.34 (s, 1H), 6.32 (s, 1H), 5.21 (t, J=8 Hz, 1H), 3.64 (s, 4H), 3.29 (s, 1H), 3.06 (m, 4H), 2.87 (s, 1H), 2.78 (s, 1H), 2.59 (d, J=8 Hz, 1H), 2.26 (d, J=8 Hz, 1H), 1.39 (d, J=8 Hz, 1H). MS: 510, 512 (M+H), HPLC: 2.02 min (G method).

Provenance & Evidence