2-Pyrazol-1-yl-benzaldehyde → HCID 178513966, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50 mg, 0.148 mmol) and 2-Pyrazol-1-yl-benzaldehyde (28 mg, 0.163 mmol) were reacted to produce 33 mg (45%) of the title compound. mp: 120° C., 1H NMR (300 MHz, DMSO-d6): 12.88 (s, 1H), 8.00 (s, 1H), 7.82 (d, J=8 Hz, 1H), 7.77 (s, 1H), 7.66 (m, 3H), 7.60 (m, 1H), 7.57 (s, 1H), 7.16 (s, 1H), 7.04 (d, J=8 Hz, 1H), 6.37 (s, 1H), 6.22 (s, 1H), 6.10 (s, 1H), 4.87 (t, J=8 Hz, 1H), 3.32 (s, 1H), 2.80 (s, 1H), 2.16 (d, J=8 Hz, 1H), 1.31 (d, J=8 Hz, 1H). MS: 490, 492 (M+H), HPLC: 2.28 min (G method).

Provenance & Evidence