反应详情

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50 mg, 0.148 mmol) and 2,6-Dimethoxy-benzaldehyde (27 mg, 0.163 mmol) were reacted to produce 49 mg (68%) of the title compound. mp: 194-197° C., 1H NMR (300 MHz, DMSO-d6): 12.6 (s, 1H), 8.00 (s, 1H), 7.57 (s, 1H), 7.45 (t, J=8 Hz, 1H), 7.12 (s, 1H), 6.80 (d, J=8 Hz, 2H), 6.23 (br s, 1H), 6.17 (br s, 1H), 5.14 (t, J=8 Hz, 1H), 3.73 (s, 6H), 2.84 (s, 1H), 2.69 (s, 1H), 2.54 (d, J=8 Hz, 1H), 2.25 (d, J=8 Hz, 1H), 2.09 (s, 1H), 1.38 (d, J=8 Hz, 1H). MS: 484, 486 (M+H), HPLC: 2.33 min (G method)