3-Furaldehyde → HCID 178513981, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50 mg, 0.148 mmol) and 3-Furaldehyde (15.6 mg, 0.163 mmol) were reacted to produce 33 mg (54%) of the title compound. mp: 231-232° C., 1H NMR (300 MHz, DMSO-d6): 13.1 (s, 1H), 8.31 (s, 1H), 8.00 (s, 1H), 7.84 (s, 1H), 7.74 (br s, 1H), 7.21 (s, 1H), 7.10 (d, J=8 Hz, 1H), 7.01 (s, 1H), 6.40 (br s, 1H), 6.33 (br s, 1H), 5.15 (t, J=8 Hz, 1H), 2.87 (s, 1H), 2.74 (s, 1H), 2.60 (d, J=8 Hz, 1H), 2.23 (d, J=8 Hz, 1H), 1.37 (d, J=8 Hz, 1H). MS: 414-416 (M+H), HPLC: 2.27 min (G method)

Provenance & Evidence