6-(Morpholin-4-yl)pyridine-3-carbaldehyde → HCID 178513977, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50 mg, 0.148 mmol) and 6-Morpholin-4-yl-pyridine-3-carbaldehyde (31.2 mg, 0.163 mmol) were reacted to produce 56 mg (74%) of the title compound. mp: 288-290° C., 1H NMR (300 MHz, DMSO-d6): 13.14 (s, 1H), 8.87 (s, 1H), 8.21 (d, J=8 Hz, 2H), 7.98 (s, 1H), 7.74 (s, 1H), 7.20 (s, 1H), 7.02 (m, 2H), 6.36 (s, 2H), 5.25 (t, J=8 Hz, 1H), 3.72 (br s, 4H), 3.57 (br s, 4H), 3.29 (s, 1H), 2.88 (s, 1H), 2.75 (s, 1H), 2.61 (d, J=7 Hz, 1H), 2.25 (d, J=8 Hz, 1H), 1.38 (d, J=8 Hz, 1H). MS: 510, 512 (M+H), HPLC: 1.96 min (G method).

Provenance & Evidence