Ammonium Acetate → HCID 178428039, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50.00 mg, 0.1702 mmol), 2-Methyl-4-morpholin-4-yl-benzaldehyde (38.4 mg, 0.187 mmol), and Ammonium acetate (26.2 mg, 0.340 mmol) were reacted to produce 28.37 mg (35%) of the title compound. (300 MHz, DMSO-d6) 12.83 (s, 1H), 7.91 (s, 1H), 7.72 (m, 2H), 7.21 (s, 1H), 7.00 (d, J=9 Hz, 1H), 6.90 (s, 2H), 6.33 (s, 1H), 6.26 (s, 1H), 5.18 (t, J=17 Hz, 9 Hz, 1H), 3.75 (s, 4H), 3.22 (s, 4H), 2.86 (s, 1H), 2.75 (s, 1H), 2.59 (d, J=8 Hz, 1H), 2.25 (d, J=8 Hz, 1H), 1.39 (d, J=8 Hz). MS=479 (M+H), HPLC: 2.42 min. (G Method)

Provenance & Evidence