Ammonium Acetate → HCID 178434059, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50.00 mg, 0.1702 mmol), 1,3-Dimethyl-5-morpholin-4-yl-1H-pyrazole-4-carbaldehyde (39.2 mg, 0.187 mmol), and Ammonium acetate (26.2 mg, 0.340 mmol) were reacted to produce 28.80 mg (35%) of the title compound. (300 MHz, DMSO-d6) 12.67 (s, 1H), 7.93 (s, 1H), 7.68 (m, 1H), 7.18 (s, 1H), 6.98 (d, J=8.5 Hz, 1H), 6.31 (d, J=15 Hz, 2H), 5.28 (t, J=17 Hz, 9 Hz, 1H), 3.65 (m, 7H), 3.04 (m, 4H), 2.94 (m, 2H), 2.84 (s, 1H), 2.74 (s, 1H), 2.57 (d, J=9 Hz, 1H), 2.27 (d, J=9 Hz, 1H), 2.18 (s, 3H), 1.40 (d, J=8 Hz, 1H). MS=483 (M+H), HPLC: 1.99 min. (G Method)

Provenance & Evidence