Ammonium Acetate → HCID 178494113, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50.00 mg, 0.1702 mmol), 2-Methoxy-pyridine-3-carbaldehyde (25.7 mg, 0.187 mmol), and Ammonium acetate (26.2 mg, 0.340 mmol) were reacted to produce 8.5 mg (12%) of the title compound. (300 MHz, DMSO-d6) 12.61 (s, 1H), 8.46 (d, J=7.5 Hz, 1H), 8.31 (s, 1H), 7.99 (s, 1H), 7.76 (s, 1H), 7.21 (m, 3H), 6.38 (d, J=19 Hz, 2H), 5.17 (t, J=17 Hz, J=9 Hz, 1H), 4.05 (s, 3H), 2.89 (s, 1H), 2.80 (s, 1H), 2.61 (d, J=9 Hz, 1H), 2.24 (d, J=9 Hz, 1H), 1.39 (d, J=9 Hz, 1H). MS=411 (M+H), HPLC: 2.33 min. (G Method)

Provenance & Evidence