4-Fluorobenzaldehyde → HCID 178513997, compound

Participants

Reaction Steps

In a similar fashion compound to CXXV, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50.00 mg, 0.1702 mmol), 4-Fluorobenzaldehyde (23.2 mg, 0.187 mmol), and Ammonium acetate (26.2 mg, 0.340 mmol) were reacted to yield 20.09 mg (30%) of the title compound. (300 MHz, DMSO-d6) 13.31 (s, 1H), 8.18 (s, 2H), 7.96 (m, 1H), 7.77 (s, 1H), 7.41 (m, 2H), 7.23 (s, 2H), 6.40 (m, 2H), 5.18 (t, J=17 Hz, 8.5 Hz, 1H), 2.90 (s, 1H), 2.78 (s, 1H), 2.63 (d, J=8 Hz, 1H), 2.24 (d, J=8 Hz, 1H), 1.38 (d, J=8 Hz, 1H). MS=398 (M+H), HPLC: 2.54 min. (G Method)

Provenance & Evidence