Ammonium Acetate → HCID 178428038, compound

Participants

Reaction Steps

In a similar fashion to compound CXXV, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (100.00 mg, 0.29568 mmol), 2-Methyl-4-morpholin-4-yl-benzaldehyde (66.8 mg, 0.325 mmol), and Ammonium acetate (45.6 mg, 0.591 mmol) were reacted to yield 48.7 mg (32%) of the title compound. (300 MHz, DMSO-d6) 12.85 (s, 1H), 8.00 (s, 1H), 7.71 (m, 2H), 7.19 (s, 1H), 6.92 (m, 2H), 6.34 (s, 1H), 6.26 (s, 1H), 5.30 (t, J=17 Hz, 8. Hz, 1H), 3.75 (s, 4H), 3.22 (s, 4H), 2.85 (s, 1H), 2.73 (s, 1H), 2.65 (s, 3H), 2.59 (d, J=8 Hz, 1H) 2.24 (d, J=8 Hz, 1H), 1.38 (d, J=8 Hz, 1H). MS=525 (M+H), HPLC: 2.43 min. (G Method)

Provenance & Evidence