Ammonium Acetate → HCID 178513980, compound

Participants

Reaction Steps

In a similar fashion to Compound CXXV, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (57.57 mg, 0.1702 mmol), 2-Morpholin-4-yl-pyridine-4-carbaldehyde (36.0 mg, 0.187 mmol), and Ammonium acetate (26.2 mg, 0.340 mmol) were reacted to produce 75.1 mg (86%) of the title compound. (300 MHz, DMSO-d6) 13.47 (s, 1H), 8.28 (d, J=5 Hz, 1H), 8.08 (s, 1H), 7.76 (s, 1H), 7.52 s, 1H), 7.36 (d, J=5 Hz, 1H), 7.33 (d, J=8 Hz, 1H), 7.24 (s, 1H), 6.39 (s, 2H), 5.20 (t, J=17 Hz, 8.5 Hz, 1H), 3.75 (m, 4H), 3.54 (s, 4H), 2.90 (s, 1H), 2.79 (s, 1H), 2.62 (d, J=8 Hz, 1H), 2.24 (d, J=8 Hz, 1H), 1.38 (d, J=8 Hz, 1H). MS=512 (M+H), HPLC: 1.78 min. (G Method)

Provenance & Evidence