Ammonium Acetate → HCID 178513970, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (75.00 mg, 0.2218 mmol), 6-Trifluoromethyl-pyridine-3-carbaldehyde (42.7 mg, 0.244 mmol), and Ammonium acetate (34.2 mg, 0.444 mmol) were reacted to produce 5.98 mg (5%) of the title compound. (300 MHz, DMSO-d6) 9.45 (s, 1H), 8.69 (d, J=9 Hz, 1H), 8.09 (m, 2H), 7.76 (s, 1H), 7.22 (s, 2H), 6.44 (m, 1H), 6.37 (m, 1H), 5.24 (t, J=17 Hz, 8 Hz, 1H), 2.89 (s, 1H), 2.79 (s, 1H), 2.66 (d, J=9 Hz, 1H), 2.63 (d, J=9 Hz, 1H), 2.25 (d, J=8 Hz, 1H), 1.39 (d, J=8 Hz, 1H). MS=493 (M+H), HPLC: 2.66 min. (G Method)

Provenance & Evidence