3-Chlorobenzaldehyde → HCID 178513988, compound

Participants

Reaction Steps

In a similar fashion to Compound CXXV, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (75.00 mg, 0.2553 mmol), 3-Chlorobenzaldehyde (39.5 mg, 0.281 mmol), and Ammonium acetate (39.4 mg, 0.511 mmol) were reacted to produce 31.23 mg (30%) of the title compound. (300 MHz, DMSO-d6) 13.42 (s, 1H), 8.19 (s, 1H), 8.10 (d, J=8 Hz, 1H), 7.98 (s, 1H), 7.78 (s, 1H), 7.62-7.53 (m, 2H), 7.32 (d, J=9 Hz, 1H), 7.25 (s, 1H), 6.39 (s, 2H), 5.18 (t, J=17 Hz, 9 Hz, 1H), 2.87 (s, 1H), 2.91 (s, 1H), 2.81 (d, J=8 Hz, 1H), 2.63 (d, J=8 Hz, 1H), 2.23 (d, J=8 Hz, 1H), 1.38 (d, J=8 Hz, 1H). MS=414 (M+H), HPLC: 2.73 min. (G Method)

Provenance & Evidence