4-Chlorobenzaldehyde → HCID 178513971, compound

Participants

Reaction Steps

In a similar fashion to Compound CXXV, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (86.35 mg, 0.2553 mmol), 4-Chlorobenzaldehyde (39.5 mg, 0.281 mmol) and Ammonium acetate (39.4 mg, 0.511 mmol) were reacted to produce 72.70 mg (63%) of the title compound. (300 MHz, DMSO-d6) 13.39 (s, 1H), 8.14 (d, J=9 Hz, 1H), 8.04 (s, 1H), 7.75 (s, 1H), 7.63 (d, J=9 Hz, 2H), 7.21 (m, 2H), 6.41 (m, 1H), 6.37 (m, 1H), 5.21 (t, J=17 Hz, 9 Hz, 1H), 2.89 (s, 1H), 2.77 (s, 1H), 2.62 (d, J=9 Hz, 1H), 2.23 (d, J=9 Hz, 1H), 1.38 (d, J=9 Hz, 1H). MS=458 (M+H), HPLC: 2.77 min. (G Method)

Provenance & Evidence