4-Cyanobenzaldehyde → HCID 178509628, compound

Participants

Reaction Steps

In a similar fashion to Compound CXXV, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (75 mg, 0.22 mmol), 4-Formylbenzonitrile (32.0 mg, 0.244 mmol), and Ammonium acetate (34.2 mg, 0.444 mmol) were reacted to produce 47.01 mg (47%) of the title compound. (300 MHz, DMSO-d6) 13.60 (s, 1H), 8.29 (d, J=8 Hz, 2H), 8.08 (s, 1H), 7.76 (s, 1H), 7.31 (m, 1H), 7.24 (s, 1H), 6.42 (m, 1H), 6.37 (m, 1H), 5.20 (t, J=17 Hz, 8.5 Hz, 1H), 2.90 (s, 1H), 2.79 (s, 1H), 2.62 (d, J=8 Hz, 1H), 2.24 (d, J=8 Hz, 1H), 1.38 (d, J=8 Hz, 1H). MS=451 (M+H), HPLC: 2.43 min. (G Method)

Provenance & Evidence