2-Chlorobenzaldehyde → HCID 178513987, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (75.00 mg, 0.2553 mmol), 2-Chlorobenzaldehyde (39.4 mg, 0.281 mmol), and Ammonium acetate (39.4 mg, 0.511 mmol) were reacted to produce 24.35 mg (23%) of the title compound. (300 MHz, DMSO-d6) 13.15 (s, 1H), 7.99 (s, 1H), 7.84 (m, 1H), 7.74 (s, 1H), 7.64 (m, 1H), 7.53 (m, 2H), 7.20 (m, 2H), 6.29 (s, 2H), 5.14 (t, J=17 Hz, 8.5 Hz, 1H), 2.86 (s, 1H), 2.79 (s, 1H), 2.58 (d, J=8 Hz, 1H), 2.23 (d, J=8 Hz, 1H), 1.38 (d, J=8 Hz, 1H). MS=414 (M+H), HPLC: 2.49 min. (G Method)

Provenance & Evidence