2-Chlorobenzaldehyde → HCID 178513965, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (75 mg, 0.22 mmol), 2-Chlorobenzaldehyde (34.3 mg, 0.244 mmol), and Ammonium acetate (34.2 mg, 0.444 mmol) were reacted to produce 50.82 mg (50%) of the title compound. (300 MHz, DMSO-d6) 13.16 (s, 1H), 8.07 (s, 1H), 7.84 (m, 1H), 7.72 (s, 1H), 7.64 (m, 1H), 7.52 (m, 2H), 7.20 (s, 1H), 7.14 (d, J=9 Hz, 1H), 6.29 (s, 2H), 5.21 (t, J=17 Hz, 8.5 Hz, 1H), 2.86 (s, 1H), 2.77 (s, 1H), 2.57 (d, J=8 Hz, 1H), 2.24 (d, J=8 Hz, 1H), 1.38 (d, J=8 Hz, 1H). MS=460 (M+H), HPLC: 2.46 min. (G Method)

Provenance & Evidence