Ammonium Acetate → HCID 178434019, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (75 mg, 0.22 mmol), 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde (33.7 mg, 0.244 mmol), and Ammonium acetate (34.2 mg, 0.444 mmol) were reacted to produce 63.66 mg (64%) of the title compound. (300 MHz, DMSO-d6) 12.46 (s, 1H), 7.99 (s, 1H), 7.70 (s, 1H), 7.19 (s, 1H), 7.93 (d, J=9 Hz, 1H), 6.32 (m, 1H), 6.25 (m, 1H), 5.23 (t, J=17 Hz, 9 Hz, 1H), 3.76 (s, 3H), 2.85 (s, 1H), 2.75 (s, 1H), 2.57 (d, J=9 Hz, 1H), 2.47 (s, 3H), 2.35 (s, 3H), 2.25 (d, J=8 Hz, 1H), 1.39 (d, J=8 Hz, 1H). MS=458 (M+H), HPLC: 2.0 min. (G Method)

Provenance & Evidence