Ammonium Acetate → HCID 178483048, compound

Participants

Reaction Steps

In a similar fashion to Compound CXXV, (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (75.00 mg, 0.2553 mmol), 4-Chloro-2-dimethylamino-thiazole-5-carbaldehyde (53.5 mg, 0.281 mmol), and Ammonium acetate (39.4 mg, 0.511 mmol) were reacted to produce 36.84 mg (33%) of the title compound. (300 MHz, DMSO-d6) 12.56 (s, 1H), 8.00 (s, 1H), 7.73 (s, 1H), 7.18 (m, 2H), 6.34 (s, 2H), 5.04 (t, J=17 Hz, 8.5 Hz, 1H), 3.11 (s, 6H), 2.87 (s, 1H), 2.75 (s, 1H), 2.58 (s, 1H), 2.19 (d, J=8 Hz, 1H), 1.36 (d, J=8 Hz, 1H). MS=509 (M+H), HPLC: 2.39 min. (G Method).

Provenance & Evidence