Ammonium Acetate → HCID 178484585, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, 4-Chloro-2-morpholin-4-yl-thiazole-5-carbaldehyde (75.00 mg, 0.3223 mmol), (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid dimethylamide (93.35 mg, 0.2901 mmol) and Ammonium acetate (44.72 mg, 0.5802 mmol) were reacted to produce 24.34 mg (16%) of the title compound. (300 MHz, DMSO-d6) 12.80 (s, 1H), 7.96 (s, 1H), 6.42-6.32 (m, 2H), 5.11 (t, J=17 Hz, 8.5 Hz, 1H), 3.73 (m, 4H), 3.48 (m, 4H), 3.01 (d, J=9 Hz, 1H), 2.94 (s, 3H), 2.86 (m, 4H), 2.82 (s, 1H), 2.11 (d, J=8 Hz, 1H), 1.42 (d, J=8 Hz, 1H). MS=533 (M+H), HPLC: 2.73 min. (G Method)

Provenance & Evidence