Ammonium Acetate → HCID 178513984, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, 4-Chloro-2-pyrrolidin-1-yl-thiazole-5-carbaldehyde (204.9 mg, 0.9456 mmol), (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (290 mg, 0.85 mmol), and Ammonium acetate (131.2 mg, 1.702 mmol) were reacted to produce 23.46 mg (5%) of the title compound. (300 MHz, DMSO-d6) 2.68 (s, 1H), 8.00 (s, 1H), 7.74 (m, 2H), 7.23 (s, 1H), 7.13 (m, 1H), 6.38-6.31 (m, 2H), 5.05 (t, J=17 Hz, 8.5 Hz, 1H), 3.44 m, 4H), 2.87 (s, 1H), 2.73 (s, 1H), 2.58 (d, J=8 Hz, 1H), 2.21 (d, J=8 Hz, 1H), 2.01 (m, 5H). MS=535 (M+H), HPLC: 2.54 min. (G Method)

Provenance & Evidence