Ammonium Acetate → HCID 178484584, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, 4-Chloro-2-(3-hydroxy-pyrrolidin-1-yl)-thiazole-5-carbaldehyde (180.77 mg, 0.77687 mmol), (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid dimethylamide (200.00 mg, 0.62149 mmol) and Ammonium acetate (95.813 mg, 1.2430 mmol) were reacted to produce 35.95 mg (11%) of the title compound. (300 MHz, DMSO-d6) 12.70 (s, 1H), 7.95 (s, 1H), 6.66 (s, 1H), 6.42-6.34 (m, 2H), 5.76 (s, 1H), 5.13 (m, 2H), 4.44 (s, 1H), 3.54 (m, 3H), 3.03 (d, J=9 Hz, 1H), 2.95 (s, 3H), 2.86 (m, 4H), 2.83 (m, 4H), 2.11 (d, J=9 Hz, 1H), 1.96 (m, 1H), 1.42 (d, J=9 Hz, 1H). MS=533 (M+H), HPLC: 2.33 min. (G Method)

Provenance & Evidence