Ammonium Acetate → HCID 117701743, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, 4-Chloro-2-(3-hydroxy-pyrrolidin-1-yl)-thiazole-5-carbaldehyde (180.77 mg, 0.77687 mmol), (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid isopropylamide (208.72 mg, 0.62149 mmol), and Ammonium acetate (95.813 mg, 1.2430 mmol) were reacted to produce 23.87 mg (7%) of the title compound. (300 MHz, DMSO-d6) 12.60 (s, 1H), 8.10 (d, J=7 Hz, 1H), 7.92 (s, 1H), 6.38-6.31 (m, 2H), 5.16 (m, 1H), 5.02 (T, J=17 Hz, 9 Hz, 1H), 4.44 (s, 1H), 3.88 (m, 1H), 3.54 (m, 3H), 2.83 (s, 1H), 2.76 (s, 1H), 2.55 (d, J=8 Hz, 1H), 2.24 (d, J=8 Hz, 1H), 2.10 (m, 1H), 1.96 (m, 1H), 1.38 (d, J=8 Hz, 1H), 1.06 (d, J=7 Hz, 3H), 0.99 (d, J=7 Hz, 3H). MS=548 (M+H), HPLC: 2.52 min. (G Method)

Provenance & Evidence