Ammonium Acetate → HCID 178513985, compound

Participants

Reaction Steps

In a similar fashion to Compound LXXXVII, 4-Chloro-2-(3-hydroxy-pyrrolidin-1-yl)-thiazole-5-carbaldehyde (180.77 mg, 0.77687 mmol), (1S,2S,3R,4R)-3-(2,3-Diamino-5-bromo-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (210.19 mg, 0.62149 mmol), and Ammonium acetate (95.813 mg, 1.2430 mmol) were reacted to produce 13.82 mg (4%) of the title compound. (300 MHz, DMSO-d6) 12.68 (s, 1H), 8.01 (s, 1H), 7.73 (s, 1H), 7.23 (s, 1H), 7.14 (s, 1H), 6.38-6.31 (m, 2H), 5.15 (s, 1H), 5.05 (t, J=17 Hz, 8.5 Hz, 1H), 4.44 (s, 1H), 3.54 (m, 3H), 2.87 (s, 1H), 2.73 (s, 1H), 2.59 (d, J=8 Hz, 1H), 2.21 (d, J=8 Hz, 1H), 2.10 (m, 1H), 1.96 (m, 1H), 1.38 (d, J=8 Hz, 1H). MS=553 (M+H), HPLC: 2.07 min. (G Method)

Provenance & Evidence