HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 592056Generated: October 31, 2026
Diisopropylethylamine → HCID 89738582, compound
https://huagongshe.com/reaction/592056
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Amino-4,5-dichloro-3-nitropyridine | HCID 46867660 | — |
| Reactant | HCID 89738583 | HCID 89738583 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 89738582 | HCID 89738582 | 100.7% |
Reaction Steps
(1S,2R,3S,4R)-3-amino-7-oxabicyclo[2.2.1]heptane-2-carboxamide (15) (170 mg, 0.67 mmol), 4,5-dichloro-3-nitropyridin-2-amine (127 mg, 0.6 mmol), DIPEA (5.5 eq) were taken in IPA and heated at 60° C. for 15 h when a yellow precipitate appeared. The precipitate was filtered, washed well with IPA and dried to afford the desired product, (198 mg, 34%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09238656B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-eb295ac296f1431393cf5b542760d782 |
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| Source note | uspto-grants-2016_01 |
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