HCID 89738582, compound → HCID 131734539, compound

Participants

Reaction Steps

To a suspension of Raney Nickel (70 mg) in MeOH (25 ml) (1S,2R,3S,4R)-3-(2-amino-5-chloro-3-nitropyridin-4-ylamino)-7-oxabicyclo[2.2.1]heptane-2-carboxamide (16) (150 mg, 0.458 mmol) was added and the reaction mixture was hydrogenated for 2 h at rt. The reaction mixture was filtered through a bed of celite and the bed was washed well with MeOH. The filtrate was concentrated to afford the product (131 mg, 96%) as a white solid. LCMS (254 nm): [M+H]+ 298.10 (99.9%)

Provenance & Evidence