HCID 178452350, compound → HCID 178513990, compound

Participants

Reaction Steps

tert-butyl 4-(3-(7-((1R,2R,3S,4S)-3-carbamoylbicyclo[2.2.1]hept-5-en-2-ylamino)-6-chloro-3H-imidazo[4,5-b]pyridine-2-yl)benzoyl)piperazine-1-carboxylate (18) (160 mg, 0.27 mmol) was dissolved in 2 mL of 20% TFA solution in DCM. The reaction mixture was stirred at room temperature for 6 h. After 6 h, DCM was evaporated and the residue was triturated with ether to obtain the desired product (75 mg, 56% yield) as a light brown hygroscopic solid.

Provenance & Evidence